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Our Research
About the Applied Dynamic Mechanics Laboratory
The Applied Dynamic Mechanics Laboratory at the University of Connecticut investigates how molecular structure, mechanical forces, and interactions among individual components shape biological and autonomous systems. Our research combines experiments, mathematical modeling, computational simulation, and machine learning.
In cellular mechanics, we study how membrane and cytoskeletal organization govern the deformation, adhesion, protein diffusion, and stability of red blood cells and neurons. Atomic force microscopy, force spectroscopy, advanced fluorescence microscopy, and coarse-grained molecular dynamics connect molecular mechanisms to cellular behavior in health, disease, and injury, including sickle cell disease and axonal damage.
Our robotics research develops compact autonomous underwater vehicles (mini-AUVs), integrating computer vision, deep reinforcement learning, and docking systems. Simulations and underwater experiments support navigation, obstacle avoidance, and multi-agent coordination for inspection of submerged hulls, ports, and bridge foundations.
In applied quantum computing, we explore hybrid quantum–classical methods for swarm navigation and investigate how local decisions produce collective behavior. We also investigate quantum reservoir computing for temporal information processing, swarm dynamics, and electroencephalogram (EEG) classification in epilepsy and mild traumatic brain injury.
Across these areas, our goal is to establish predictive models, explain complex behavior, and develop experimentally grounded methods that advance cellular biophysics, intelligent autonomy, and efficient computation.
Research & Lab News
- Differential Control of Small-conductance Calcium-activated Potassium Channel Diffusion by Actin in Different Neuronal Subcompartments May 11, 2023Small-conductance calcium-activated potassium (SK) channels show a ubiquitous distribution on neurons, in both somatodendritic and axonal regions. SK channels are associated with neuronal activity regulating action potential frequency, dendritic excitability, and synaptic plasticity. Although the physiology of SK channels and the mechanisms that control their surface expression levels have been investigated extensively, little is known […]Shiju Gu
- Dynamics of the axon plasma membrane skeleton March 20, 2023It was recently revealed via super-resolution microscopy experiments that the axon plasma membrane skeleton (APMS) comprises a series of periodically arranged azimuthal actin rings connected via longitudinal spectrin filaments forming an orthotropic network. The common perception is that APMS enhances structural stability of the axon but its impact on axon deformation is unknown. To investigate […]Zhaojie Chai
College News
- Professor Sir Cato T. Laurencin Delivers Keynote Address at the Advanced Therapies in Orthopaedics (ATiO) Foundation Annual Meeting November 2, 2026Laurencin spoke on Regenerative Engineering at the 2026 ATiO Conference in Berlin, Germany.Sara Capozzi
- UConn to Advise Greece on Energy Resilience and Safety October 29, 2026The Alexandroupolis region of Greece has become an important gateway for natural gas supply to southeastern and central Europe following Russia’s invasion of Ukraine. UConn will provide expertise to ensure energy resilience, environmental safety, and economic development for the regionMatt Engelhardt
- Professor Sir Cato T. Laurencin Named UConn Engineering Faculty Innovator of the Year October 27, 2026The award recognizes Laurencin’s technological innovations with significant real-world impact.Sara Capozzi
- Professor Sir Cato T. Laurencin Delivers Keynote Address at the National Academy of Inventors 15th Annual Conference October 26, 2026Laurencin Gives Talk on Regenerative Engineering with a Book Signing at Los Angeles Conference.Sara Capozzi
UConn Community News
- Professor Emeritus George Y. Wu Honored November 2, 2026The award recognized a lifetime of achievement and public service in medicine.
- Professor Sir Cato T. Laurencin Delivers Keynote Address at the Advanced Therapies in Orthopaedics (ATiO) Foundation Annual Meeting November 2, 2026Laurencin spoke on Regenerative Engineering at the 2026 ATiO Conference in Berlin, Germany.
- A Worldclass Window into a Worldclass Collection November 2, 2026Explore UConn’s impressive botanical conservatory in-person or virtually
- Wishing Upon Even Star Political Candidates Can Be Dangerous November 2, 2026UConn political science researcher finds so-called ‘wishful thinking’ correlates with such negatives as polarization, animosity toward opposing side