Neuronal cell mechanics: AFM stiffness measurements, STED microscopy, periodic axon membrane skeleton, and fluorescence and molecular simulation images.Conceptual illustration based on laboratory photographs: three transparent mini-AUVs with green thrusters following coordinated underwater paths.Conceptual illustration of a quantum processor with a mechanical lattice and control-system trajectories

About the Applied Dynamic Mechanics Laboratory

The Applied Dynamic Mechanics Laboratory at the University of Connecticut investigates how molecular structure, mechanical forces, and interactions among individual components shape biological and autonomous systems. Our research combines experiments, mathematical modeling, computational simulation, and machine learning.

In cellular mechanics, we study how membrane and cytoskeletal organization govern the deformation, adhesion, protein diffusion, and stability of red blood cells and neurons. Atomic force microscopy, force spectroscopy, advanced fluorescence microscopy, and coarse-grained molecular dynamics connect molecular mechanisms to cellular behavior in health, disease, and injury, including sickle cell disease and axonal damage.

Our robotics research develops compact autonomous underwater vehicles (mini-AUVs), integrating computer vision, deep reinforcement learning, and docking systems. Simulations and underwater experiments support navigation, obstacle avoidance, and multi-agent coordination for inspection of submerged hulls, ports, and bridge foundations.

In applied quantum computing, we explore hybrid quantum–classical methods for swarm navigation and investigate how local decisions produce collective behavior. We also investigate quantum reservoir computing for temporal information processing, swarm dynamics, and electroencephalogram (EEG) classification in epilepsy and mild traumatic brain injury.

Across these areas, our goal is to establish predictive models, explain complex behavior, and develop experimentally grounded methods that advance cellular biophysics, intelligent autonomy, and efficient computation.


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  • Differential Control of Small-conductance Calcium-activated Potassium Channel Diffusion by Actin in Different Neuronal Subcompartments May 11, 2023
    Small-conductance calcium-activated potassium (SK) channels show a ubiquitous distribution on neurons, in both somatodendritic and axonal regions. SK channels are associated with neuronal activity regulating action potential frequency, dendritic excitability, and synaptic plasticity. Although the physiology of SK channels and the mechanisms that control their surface expression levels have been investigated extensively, little is known […]
    Shiju Gu
  • Dynamics of the axon plasma membrane skeleton March 20, 2023
    It was recently revealed via super-resolution microscopy experiments that the axon plasma membrane skeleton (APMS) comprises a series of periodically arranged azimuthal actin rings connected via longitudinal spectrin filaments forming an orthotropic network. The common perception is that APMS enhances structural stability of the axon but its impact on axon deformation is unknown. To investigate […]
    Zhaojie Chai